PSD Introduction

  • Despite the success of ART, HIV persists in reservoirs and viremia rebounds if treatment is interrupted. To facilitate understanding of the genetic structure and dynamics of the HIV reservoir, we developed a public database Proviral Sequence Database (PSD) for the storage and meta-analyses of near full-length (NFL) HIV genomic RNA and proviral sequences that persist in donors on ART or that rebound after ART is interrupted.
  • PSD is a relational database containing information about host characters, treatment, HIV sequences and the sequences annotations/features. It is sponsored by the HIV Dynamics and Replication Program (HIV DRP), National Cancer Institute, NIH. The HIV DRP is a multidisciplinary research program focusing on various aspects of HIV studies.
  • Users do not need to log in to access this database.
  • How to cite this database:
  • Shao W, Shan J, Hu WS, Halvas EK, Mellors JW, Coffin JM, Kearney MF. HIV Proviral Sequence Database: A New Public Database for Near Full-Length HIV Proviral Sequences and Their Meta-Analyses. AIDS Res Hum Retroviruses. 2019 Oct 29. doi: 10.1089/AID.2019.0214. [Epub ahead of print].

If you have any questions, or if we miss any recent publications about HIV1 NFL provirus sequences, please contact Mary Kearney, Ph.D at

© RID. Supported by Advanced Biomedical Computational Science (ABCS) at Leidos/FNLCR.